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primidone will reduce the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Modafinil appeared to make a concentration-linked suppression of CYP2C9 activity, hence suggesting possible for CYP2C9 inhibition; caution if medicine which have a slim therapeutic indexfedratinib will boost the leve